abstract：:We were interested in determining the effect of enflurane, halothane, and isoflurane on the uptake and removal of 5-hydroxytryptamine (5-HT) and phenylethylamine (PEA) from the lung. Isolated rabbit lungs were perfused in a recirculating system in vitro with 0.1 microM [14C]5-HT or 0.1 microM [14C]PEA in Krebs-Ringer ...

journal_title：Anesthesia and analgesia

authors： Cook DR,Brandom BW

更新日期：1982-08-01 00:00:00

abstract：:Twenty-four male patients scheduled for elective pulmonary resection were studied to determine whether continuous insufflation of oxygen to the nonventilated lung would reduce intrapulmonary shunting (Qs/Qt) and arterial oxygen desaturation. Measurements of physiologic variables were made using pulmonary arterial and ...

journal_title：Anesthesia and analgesia

authors： Rees DI,Wansbrough SR

更新日期：1982-06-01 00:00:00

abstract：:A parametric study was performed in cats comparing the effects on the brainstem auditory evoked response of four anesthetic agents used either in the operating room or the laboratory: sodium pentobarbital, ketamine, halothane, and chloralose. Each anesthetic agent was administered to each of four cats in varying seque...

journal_title：Anesthesia and analgesia

authors： Cohen MS,Britt RH

更新日期：1982-04-01 00:00:00

abstract：:Hypotensive effects of the intravenous injection of adenine compounds [adenosine triphosphate (ATP), adenosine] were compared with those of sodium nitroprusside (SNP) in rabbits during light, stable halothane anesthesia. ATP and adenosine were almost equipotent in their effects on blood pressure and heart rate. The hy...

journal_title：Anesthesia and analgesia

authors： Fukunaga AF,Flacke WE,Bloor BC

更新日期：1982-03-01 00:00:00

abstract：:Sufentanil is a new synthetic opiate analgesic that is 4520 times more potent than morphine in animal experiments. This study evaluated the cardiovascular effects of sufentanil, 15 micrograms/kg, and air/O2 used as a complete anesthetic with 50% inspired oxygen (air/O2 mixture) in 40 adult patients undergoing elective...

journal_title：Anesthesia and analgesia

authors： Sebel PS,Bovil JG

更新日期：1982-02-01 00:00:00

abstract：:Large doses of morphine sulfate have been reported to cause myocardial lactate production and reduction in coronary blood flow in animals. Similar effects with clinical doses in man would significantly alter the management of cardiac patients. Eleven adult patients with significant coronary arterial disease and normal...

journal_title：Anesthesia and analgesia

authors： Sethna DH,Moffitt EA,Gray RJ,Bussell J,Raymond M,Conklin C,Shell WE,Matloff JM

更新日期：1982-02-01 00:00:00

abstract：:Activity of methionine synthetase was measured in liver biopsies of seven patients who had received 50% to 70% nitrous oxide supplemented by a combination of a narcotic and/or barbiturate with or without a volatile anesthetic, and from seven patients who were anesthetized without nitrous oxide (control group). Methion...

journal_title：Anesthesia and analgesia

authors： Koblin DD,Waskell L,Watson JE,Stokstad EL,Eger EI 2nd

更新日期：1982-02-01 00:00:00

abstract：:Lumbar cerebrospinal fluid levels of 5-hydroxyindoleacetic acid, which are used as indicators of central nervous system serotonergic neuronal activity, were significantly higher in 67 patients with chronic pain and in 32 patients with acute pain (23.6 +/- 3.3 and 23.1 +/- 3.8, respectively) than in 30 patients (8.8 +/...

journal_title：Anesthesia and analgesia

authors： Ghia JN,Mueller RA,Duncan GH,Scott DS,Mao W

更新日期：1981-12-01 00:00:00

abstract：:This study was conducted to assess the learning function of murine progeny born of mothers that had received either 1% or 2% halothane or 2% or 4% enflurane, on days 6 and 10 or days 14 and 17 or gestation. Their timed performance at the age of 6 to 7 weeks was compared in a maze with that of control mice of similar a...

journal_title：Anesthesia and analgesia

authors： Chalon J,Tang CK,Ramanathan S,Eisner M,Katz R,Turndorf H

更新日期：1981-11-01 00:00:00

abstract：:Acid-base status and blood levels of bupivacaine were determined in 16 diabetic parturients and their infants after epidural anesthesia for cesarean section. The newborn infants were divided into two groups based on umbilical artery pH at birth. Group A consisted of 10 infants who had a pH of less than 7.2 and group B...

journal_title：Anesthesia and analgesia

authors： Datta S,Brown WU Jr,Ostheimer GW,Weiss JB,Alper MH

更新日期：1981-08-01 00:00:00

abstract：:Median convulsant (CD50) and median lethal (LD50) doses of intraperitoneal lidocaine, bupivacaine, and etidocaine were determined in 149 mice. Another 496 mice were pretreated with intramuscular diazepam, lorazepam, or midazolam, 1 mg/kg. Fifteen minutes later, lidocaine, bupivacaine, or etidocaine was given intraperi...

journal_title：Anesthesia and analgesia

authors： de Jong RH,Bonin JD

更新日期：1981-06-01 00:00:00

abstract：:In 10 premature infants (1123 +/- 263 g), fentanyl citrate (30 to 50 microgram/kg) was used in conjunction with pancuronium (0.1 mg/kg) as the sole anesthetic for transthoracic ligation of patent ductus arteriosus. Ventilation was controlled with air and oxygen in concentrations sufficient to maintain transcutaneous P...

journal_title：Anesthesia and analgesia

authors： Robinson S,Gregory GA

更新日期：1981-05-01 00:00:00

abstract：:Sevoflurane, 3% and 4% in oxygen was administered to four dogs for 3 hours. Sevoflurane was metabolized to inorganic fluoride and hexafluoroisopropanol. Serum fluoride concentrations reached peak values during 2 to 3 hours into anesthesia and averaged 18.5 micrometer/L (n = 2) and 20.0 +/- 4.8 (mean +/- SD) micrometer...

journal_title：Anesthesia and analgesia

authors： Martis L,Lynch S,Napoli MD,Woods EF

更新日期：1981-04-01 00:00:00

abstract：:Mice continuously exposed to 50% nitrous oxide for 2 weeks or more become tolerant to nitrous oxide, as measured by an 8% to 19% increase in their nitrous oxide ED50 (the dose required to abolish the righting reflex in 50% of the animals). Control mice tolerant to nitrous oxide were given intraperitoneal injections of...

journal_title：Anesthesia and analgesia

authors： Koblin DD,Deady JE,Nelson NT,Eger EI 2nd,Bainton CR

更新日期：1981-03-01 00:00:00

abstract：:In chloralose-anesthetized dogs the hypotensive and reflex cardiovascular responses to infusions of sodium nitroprusside were studied before and during halothane and enflurane, and before after divided doses of cryptenamine. The latter drug, a mixture of hypotensive veratrum alkaloids, lowers blood pressure reflexly b...

journal_title：Anesthesia and analgesia

authors： Flacke JW,Flacke WE,Cant JW

更新日期：1980-12-01 00:00:00

abstract：:A study of the effects of halothane on the cyclic 3',5'-adenosine monophosphate (cAMP) system in human platelets was undertaken since cAMP has been implicated in the regulation of the process of platelet aggregation and this anesthetic has been reported to decrease platelet aggregation and, in other tissues, to increa...

journal_title：Anesthesia and analgesia

authors： Walter F,Vulliemoz Y,Verosky Y,Triner L

更新日期：1980-11-01 00:00:00

abstract：:Roentgenograms of iothalamate meglumine 60% (Conray) injected bilaterally into the intercostal grooves of the ninth or tenth ribs in 30 surgical patients showed extensive spread of the contrast central and peripherally from the site of injection within 30 seconds, with almost complete absorption within 10 minutes 30 s...

journal_title：Anesthesia and analgesia

authors： Moore DC,Bush WH,Scurlock JE

更新日期：1980-11-01 00:00:00

abstract：:Sensory level of anesthesia following the injection of 20 ml of 1.5% lidocaine with epinephrine (1:200,000) in 238 adult males averaged T7.7, T5.6, and T5.1 at 10, 20, and 30 minutes, respectively. Patient age had no significant effect on local anesthetic requirements per spinal segment per unit height until age 40 ye...

journal_title：Anesthesia and analgesia

authors： Park WY,Massengale M,Kim SI,Poon KC,Macnamara TE

更新日期：1980-10-01 00:00:00

abstract：:Contraction of the adductor of the thumb in response to ulnar nerve stimulation during continuous infusion of succinylcholine (SCh) was evaluated in 22 children anesthetized with halothane (1% to 1.5%) and N2O/O2. Twitch rates of 0.1 Hz were used to evaluate the force of contraction. Train-of-four stimulation (2 Hz fo...

journal_title：Anesthesia and analgesia

authors： DeCook TH,Goudsouzian NG

更新日期：1980-09-01 00:00:00

abstract：:In a double-blind, single-dose study hydroxyzine combined with morphine was administered intramuscularly to postoperative patients to determine the efficacy of this combination in the relief of postoperative pain, and to compare its effect to that produced by morphine alone. Eighty-two patients received morphine (5 or...

journal_title：Anesthesia and analgesia

authors： Hupert C,Yacoub M,Turgeon LR

更新日期：1980-09-01 00:00:00

abstract：:Effects of halothane, enflurane, and nitrous oxide on ciliary beats were evaluated using a photoelectric system in dissected rabbit tracheal segments. Dose-dependent suppression of the frequency of ciliary beats of moderate degrees was observed after exposure of tracheal segments to warmed and humidified vapors of hal...

journal_title：Anesthesia and analgesia

authors： Lee KS,Park SS

更新日期：1980-06-01 00:00:00

abstract：:The performance of five of the most commonly used halothane vaporizers and three enflurane vaporizers was tested under conditions encountered in low-flow and closed-circuit anesthesia. Anesthetic gas concentrations were measured continuously with a mass spectrometer connected to a circle system. The results indicated ...

journal_title：Anesthesia and analgesia

authors： Lin CY

更新日期：1980-05-01 00:00:00

abstract：:The suction-biopsy channel of a flexible bronchofiberscope was used to provide subglottic jet ventilation in six dogs and eight adult human subjects. In dogs, after 75 minutes of ventilation at a driving pressure of 2580 torr/cm2 (50 lb/in2) the PaO2 was 412 +/- 18 torr and the PaCO2 32 +/- 3 torr with a peak airway p...

journal_title：Anesthesia and analgesia

authors： Satyanarayana T,Capan L,Ramanathan S,Chalon J,Turndorf H

更新日期：1980-05-01 00:00:00

abstract：:Cardiac output characteristically decreases during trimethaphan infusion but is well maintained or increased during sodium nitroprusside infusion. We postulated that at similar levels of mean arterial pressure, sodium nitroprusside might be associated with greater blood loss than trimethaphan due to the increase in ca...

journal_title：Anesthesia and analgesia

authors： Sivarajan M,Amory DW,Everett GB,Buffington C

更新日期：1980-03-01 00:00:00

abstract：:The direct effect of protamine sulfate upon myocardial inotropism was studied using an isolated canine heart muscle preparation. Isometric force (F) was decreased to 87.6 +/- 1.2% of control values by a concentration of 50 x 10(-3) g/L protamine, which is approximately equal to the estimated serum concentration of pro...

journal_title：Anesthesia and analgesia

authors： Iwatsuki N,Matsukawa S,Iwatsuki K

更新日期：1980-02-01 00:00:00

abstract：:The cardiovascular responses of aortic cross-clamping and declamping with normal and high ventricular filling pressures were compared during epidural and nitrous oxide-morphine anesthesia in 32 male patients undergoing reconstructive aortic surgery. The patients were divided into four groups. Groups I and II had lumba...

journal_title：Anesthesia and analgesia

authors： Lunn JK,Dannemiller FJ,Stanley TH

更新日期：1979-09-01 00:00:00

abstract：:Serum cholinesterase levels were determined in 180 patients with carcinoma and in 146 normal subjects. Serum cholinesterase activity was significantly lower in patients suffering from cancer than in normal controls, though still within the normal range. The degree of depression of serum cholinesterase activity was inf...

journal_title：Anesthesia and analgesia

authors： Kaniaris P,Fassoulaki A,Liarmakopoulou K,Dermitzakis E

更新日期：1979-03-01 00:00:00

abstract：:The effects of narcotic agents and two inhalation anesthetics on intrabiliary pressure (IBP) were measured before and after morphine (0.2 mg/kg), meperidine (2 mg/kg), fentanyl (0.002 mg/kg), or pentazocine (1 mg/kg) given intramuscularly to guinea pigs, and after halothane (0.5, 1.0, 1.5, or 2.0 MAC) or enflurane (sa...

journal_title：Anesthesia and analgesia

authors： Arguelles JE,Franatovic Y,Romo-Salas F,Aldrete JA

更新日期：1979-03-01 00:00:00

abstract：:A case of possible malignant hyperthermia in a 6-month-old child is presented. Malignant hyperthermia was manifested in this patient by persistent metabolic acidosis in the intraoperative and postoperative periods, by a rapid rise in temperature with concomitant unresponsiveness in the postoperative period, and by a p...

journal_title：Anesthesia and analgesia

authors： Faust DK,Gergis SD,Sokoll MD

更新日期：1979-01-01 00:00:00

abstract：:The rate of hydrolysis of chloroprocaine by human serum was studied in the presence and absence of a number of aminde local anesthetics and their metabolites. Bupivacaine (2.4 microgram/ml) and etidocaine (2.3 microgram/ml) caused 38% and 21% inhibition respectively of the rate of chloroprocaine hydrolysis. Circulatin...

journal_title：Anesthesia and analgesia

authors： Lalka D,Vicuna N,Burrow SR,Jones DJ,Ludden TM,Haegele KD,McNay JL

更新日期：1978-09-01 00:00:00

abstract：:Three-centimetre linear incisions were made in 90 young male Lew/f Mai rats by scalpel through skin to the investing fascia of the left flank. The skin was undermined sharply for a distance of 0.5 cm along both sides of the entire length of the incision. The wound site was closed per primam with Michel clips and left ...

journal_title：Anesthesia and analgesia

authors： Shah NK,Kripke BJ,Sanzone CF,Cosman EB

更新日期：1978-09-01 00:00:00

abstract：:We determined the effects of hyperkalemia, hypernatremia, hyperosmolality and hypo-osmolality on halothane requirement (MAC) in dogs. Hyperkalemia did not change cerebrospinal fluid potassium or MAC. Hypernatremia proportionately increased cerebrospinal fluid sodium and osmolality. MAC concomitantly increased 43%. Ser...

journal_title：Anesthesia and analgesia

authors： Tanifuji Y,Eger EI 2nd

更新日期：1978-07-01 00:00:00

abstract：:There has been no description of the hemodynamic dose-response relationship between halothane and sodium nitroprusside (SNP), although these drugs are used together frequently for induction of deliberate hypotension. Utilizing aortic root cannulation and thermister-tipped pulmonary artery catheterization, this relatio...

journal_title：Anesthesia and analgesia

authors： Bedford RF

更新日期：1978-07-01 00:00:00

abstract：:Seven anesthetized patients were studied to determine the interaction between pancuronium and lincomycin and the ability of neostigmine and 4-aminopyridine to antagonize the block. Lincomycin 600 mg given IV alone did not decrease twitch tension. An 8 to 10% decrease in twitch tension occurred when lincomycin was give...

journal_title：Anesthesia and analgesia

authors： Booij LH,Miller RD,Crul JF

更新日期：1978-05-01 00:00:00

abstract：:One-hundred and eight-five pairs of gas samples were collected from inspired gas (10 cm behind the head at nose level) and end-tidal gas of persons administering anesthesia in 3 operating rooms during daily routine anesthesia. Mean operating-room N2O concentrations from 22 to 144 ppm (volume/volume [V/V]) were measure...

journal_title：Anesthesia and analgesia

authors： Beynen FM,Knopp TJ,Rehder K

更新日期：1978-03-01 00:00:00

abstract：:Leakge of lymph following puncture of the right subclavian vein occurred in a patient, requiring a pacemaker catheter. The lymph drainage settled spontaneously after 4 days on remanipulation of the pacing wire. ...

journal_title：Anesthesia and analgesia

authors： Ryan DW

更新日期：1978-01-01 00:00:00

abstract：:In vitro experiments using guinea pig tracheal smooth muscle were performed to compare the relaxant properties of procaine, lidocaine, and ketamine following contracture induced by histamine. Procaine produced a spasmolytic effect in a dose-related manner. In the doses tested, relaxation induced by procaine was more p...

journal_title：Anesthesia and analgesia

authors： Wanna HT,Gergis SD

更新日期：1978-01-01 00:00:00

abstract：:Patients referred to the Pain Clinic at the University of Virginia Medical Center with genuine phantom pain rather than stump pain have been treated by a variety of technics. Simple revision of drug therapy has proved helpful in some instances, as has repeated injection of trigger areas or neuromata, though surgical e...

journal_title：Anesthesia and analgesia

authors： Blankenbaker WL

更新日期：1977-11-01 00:00:00

abstract：:A 6-year experience in the anesthetic management of 34 successful whole-lung lavages on 11 adult patients with pulmonary alveolar proteinosis is described. All patients were radiographically, physiologically, and symptomatically improved after the procedures. The anesthetic protocol for lung lavage includes: (1) unila...

journal_title：Anesthesia and analgesia

authors： Lippmann M,Mok MS

更新日期：1977-09-01 00:00:00

abstract：:Spontaneous positive end-expiratory pressure (sPEEP) is a simple, low-cost method of providing low to moderate levels of PEEP as an alternative to continuous positive airway pressure (CPAP), whether used alone or with continuous positive pressure ventilation (CPPV) in intermittent mandatory ventilation (IMV). The ther...

journal_title：Anesthesia and analgesia

authors： Gillick JS

更新日期：1977-09-01 00:00:00